Diabetes drug may reduce harm of steroids

Diabetes drug metformin may help reduce harmful side-effects of steroids, according to research.
Diabetes drug metformin may help reduce harmful side-effects of steroids, according to research.

A drug used to treat type 2 diabetes could help reduce harmful side effects of steroids, according to research.

Scientists from Queen Mary University of London looked at the effects of metformin on patients who were prescribed high doses of glucocorticoids, a type of steroids used to treat chronic inflammatory diseases (CID).

They believe the diabetes drug could be "simple and cheap solution" to reduce unwanted glucocorticoids side effects, which include loss of bone and muscle mass, high sugar levels, and increased risk of infection.

Marta Korbonits, professor of endocrinology at Barts and the London School of Medicine and Dentistry at Queen Mary, said: "Our findings are strikingly positive and suggest that a simple and immediately available intervention, treatment with the diabetes drug metformin, can improve the clinical status of patients on glucocorticoid treatment, even if they do not have diabetes."

"Our results suggest metformin has the potential to help these patients."

Glucocorticoids are used to treat CID where the immune system is overactive, including rheumatoid arthritis and asthma.

Long-term steroid use can lead to a potentially fatal disorder known as Cushing's syndrome.

The researchers looked at 53 non-diabetic patients with CID from Barts Health NHS Trust as part of the phase 2 clinical trial.

Metformin and placebo were administered orally to each patient for 12 weeks.

As it was a double-blind randomised trial, neither the researchers nor the volunteers knew who was taking metformin and who was receiving the placebo.

They found patients treated with metformin showed improved outcomes, which included a 30 per cent reduction in the rate of infections and lower hospital admissions, compared to the placebo group.

The study, published in the journal The Lancet Diabetes & Endocrinology, is funded by Barts Charity.

Australian Associated Press